I would try the NEW 2001. They have always been a local's favorite and now they have updated their club. You'll find all kinds of ladies there. (near Restaurant Row)

Also, the infamous Revolutions at Broadway at the Beach will get you groovin to the best of the 70's, 80's and 90's. It's been voted best nightclub 5 years in a row. (near 29th ave)

If you want to try something a little different....try Jasmine's Supper Club. They have LIVE jazz 7 nights a week and serve a complete menu. It's hidden away on the south end of Hwy 17 but it's becoming a hot spot. (near the Christmas Mouse)

Hope that helps!