I am not aware of a really nice one down that far... although the Ocean Key House and Pier House hotels are on Duval and on the water, and they are very nice and not tooooooooooo big.

The Artist House is just off Duval - in the area.
It's lovely. The Banyon House Time Share is on Whitehead near Sloppy's...

I'll nose around and see if I can get a recommendation from anyone ... if I do, I'll shoot it to ya.