It'll be packed during Memorial Day.. but not crazy like Spring Break, if that's what you have in mind.
With that being said, you should have a great time...
Boardwalk and
Summit are right next to
Spinnaker and
Club La Vela... which will be jammin for Memorial Day.
Edgewater,
Holiday Inn and
Chateau are in the middle of the strip...
Calypso and
Emerald Beach are closer to Pier Park if that's what you're looking for.
Majestic,
Plaza,
Shores of Panama and
Beach Tower are also great choices.
Just throwing this out there, but a vacation rental house might be a good idea for a large group... especially if you want to party. Try
Counts-Oakes Resort Properties... they can set you up with something nice and affordable.
And the
Gold Nugget is in town across the bridge (I'm sure the subject will come up)